However, the pathways and mechanism of CFF binding to the target receptors remain unclear. You then feel more alert and energetic, which is why many people drink coffee or tea to stay awake. However, it can also be addictive and may cause a wide range of side effects in some people. Caffeine (CFF) is a common antagonist to the four subtypes of adenosine G-protein-coupled receptors (GPCRs), which are critical drug targets for treating heart failure, cancer, and neurological diseases. In the brain, it blocks the effects of a chemical called adenosine, which makes you feel sleepy. SummaryĬaffeine consumption has been linked to improvements in metabolism, exercise performance and alertness. However, it can also come with negative side effects, especially for people who are sensitive to its effects.Ĭaffeine can be addictive, and some research indicates that genetic variations could cause people to respond differently to it ( 12, 13).Ĭaffeine intake has also been shown to affect mental health, with one study in 2,307 children associating increased caffeine consumption with higher levels of perceived anxiety and depression ( 14).Įxcess intake can also cause other side effects, including headaches, high blood pressure and sleep disturbances ( 15, 16, 17).Īdditionally, it’s recommended that women who are pregnant or breastfeeding limit their caffeine intake, as it may be linked to a higher risk of miscarriage and low birth weight ( 18, 19). Pregnant or breastfeeding women and children should. Depicted are the chemical structures of the widely used drug 'caffeine' and the endogenously produced nucleoside 'adenosine' for comparison. Caffeines effect on your health is complex it can cause minor health problems, but it can also reduce your chances of having others. Chemical structure of caffeine and adenosine. It is found in coffee, most teas, cocoa, chocolate, cola, guarana and energy drinks. In particular, research shows that it may increase metabolism, improve exercise performance and boost alertness ( 9, 10, 11). Caffeine is a stimulant that acts on the brain and nervous system. Available at: Accessed Dec 14, 2020.Caffeine consumption can have several benefits for your health. Truven Health Analytics, Greenwood Village, Colorado, USA. F1: Chemical structure of caffeine and adenosine. Caffeine has a three-dimensional structure similar to that of adenosine, which allows it to bind and block its receptors. However, caffeine doesnt slow down the cells activity like adenosine. The clinical toxicology of caffeine: A review and case study. To a nerve cell, caffeine looks like adenosine: Caffeine binds to the adenosine receptor. IOC consensus statement: dietary supplements and the high-performance athlete. It is a naturally occurring substance found in coffee, tea, chocolate, and certain other plants it is also frequently added to other products. The world anti-doing code international standard. Caffeine is the most commonly used drug in the world. What is the average caffeine consumption in the US and how does it compare globally? (Links to an external site). Caffeine and adenosine have a similar molecular structure.
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